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  • Title: Sleep propensity free-runs with the temperature, melatonin and cortisol rhythms in a totally blind person.
    Author: Nakagawa H, Sack RL, Lewy AJ.
    Journal: Sleep; 1992 Aug; 15(4):330-6. PubMed ID: 1519008.
    Abstract:
    In previous studies, we found that many totally blind people have free-running melatonin rhythms, but that free-running melatonin rhythms were not necessarily associated with periodic insomnia and daytime sleepiness. Thus, it was not clear if the circadian sleep propensity rhythm was free-running with the other circadian rhythms. In the present study, we report that the sleep propensity rhythm (as defined by an ultrashort sleep-wake schedule) free-ran with the melatonin, temperature and cortisol rhythms in a 44-year-old totally blind man even though he maintained a conventional sleep schedule and did not complain of clinically significant insomnia or excessive daytime sleepiness.
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