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  • Title: Don't skip the G1 phase: how APC/CCdh1 keeps SCFSKP2 in check.
    Author: Bashir T, Pagano M.
    Journal: Cell Cycle; 2004 Jul; 3(7):850-2. PubMed ID: 15190201.
    Abstract:
    By keeping the levels of Skp2 and Cks1 low during G(1) progression, APC/C(Cdh1) prevents unscheduled degradation of SCF(Skp2) substrates and premature entry into S phase. Thus, APC/C(Cdh1), a ubiquitin ligase involved in mitotic exit and maintenance of G(0)/G(1) phase, directly controls SCF(Skp2), a ubiquitin ligase involved in the regulation of S phase entry.
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