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  • Title: [Role of immediate hypersensitivity to airborne allergens in the pathogenesis of atopic dermatitis].
    Author: Silny P, Czarnecka-Operacz M, Silny W.
    Journal: Pol Merkur Lekarski; 2004 Mar; 16(93):245-50. PubMed ID: 15190601.
    Abstract:
    UNLABELLED: Atopic dermatitis (AD) is a chronic inflammatory skin disease associated with hyperproduction of immunoglobulin E directed against common environmental allergens. OBJECTIVES: The aim of the study was to evaluate the immediate type of immunological reaction indicated by airborne allergens in the pathomechanism of atopic dermatitis. MATERIAL AND METHODS: 529 patients with AD aged (0.5-60 years) who fulfilled basic Hanifin and Rajka criterias and 60 healthy volunteers in the control group were investigated. In order to evaluate IgE-mediated allergy to common airborne and alimentary allergens skin prick tests (SPT) were performed (26 airborne and 7 basic alimentary allergens) and concentration of serum antigen specific IgE (asigE) was measured. RESULTS: Our results indicated airborne allergy in case of 405 patients (76.6%) and food allergy only in 67 cases (12.7%). In the group of children aged 0.5-4 years food allergy was predominant but later on the predominance of airborne allergy was observed. CONCLUSIONS: We conclude that airborne allergy plays an important and predominant role in the pathomechanism of atopic dermatitis.
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