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  • Title: [Study on the immunogenicity of HIV-1 gag vaccine].
    Author: Jiang WZ, Jin NY, Li ZJ, Zhang LS.
    Journal: Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi; 2004 May; 20(3):272-3. PubMed ID: 15193215.
    Abstract:
    AIM: To detect the immunogenicity of HIV-1 gag DNA vaccine. METHODS: The serum antibody titers of the immunized mice were detected by ELISA. The numbers of spleen's CD4(+) and CD8(+) T cells were analyzed by the fluorescent antibody staining and the cytotoxic activity was determined by lactate dehydrogenase (LDH) release assay. RESULTS: The titers of the serum antibodies and the numbers and cytotoxic activity of spleen's T lymphocyte subsets had significant differences (P<0.05 and P<0.01, respectively) between pVAXGAG and pVAX1 vaccinated groups. CONCLUSION: HIV-1 DNA vaccine plasmid pVAXGAG could elicit both the specific humoral and cellular immunities in BALB/c mice.
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