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  • Title: [Passive Ca2+ influx into vesicles of the sarcoplasmic reticulum, modified by succinic anhydride].
    Author: Tugay VA, Diadiusha GP, Zimina VP.
    Journal: Ukr Biokhim Zh (1978); 1992; 64(1):88-93. PubMed ID: 1519352.
    Abstract:
    Treatment of the sarcoplasmic reticulum (SR) vesicles with succinic anhydride in concentration of 1-2 mM modifies about 20% of amino groups. It increases initial rate and changes the pH-dependence of the passive influx of Ca2+ into vesicles and does not affect either Ca(2+)-binding or maximal passive Ca(2+)-loading of the SR vesicles. It is supposed that this effect may be caused by modification of the Ca-channel gating behaviour as a result of replacement of positive surface amino groups by carboxyl groups.
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