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  • Title: Felty's syndrome: favorable response to granulocyte-macrophage colony-stimulating factor in the acute phase.
    Author: Kaiser U, Klausmann M, Kolb G, Pflüger KH, Havemann K.
    Journal: Acta Haematol; 1992; 87(4):190-4. PubMed ID: 1519433.
    Abstract:
    We report a case of Felty's syndrome in which infectious complications due to severe neutropenia could be overcome by short-term treatment with recombinant human granulocyte-macrophage colony-stimulating factor (GM-CSF, 7 micrograms/kg/day s.c.). Leukocyte counts rose from 1,050/mm3 at presentation to 4,470/mm3 after 15 days of treatment. A flare-up of arthritis was not noted. Defects in granulocyte function and clinical improvement prior to leukocyte rise suggest that the beneficial effect of GM-CSF is mainly due to an improvement of granulocyte function.
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