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  • Title: The role of transthyretin in the transport of thyroid hormone to cerebrospinal fluid and brain.
    Author: Chanoine JP, Braverman LE.
    Journal: Acta Med Austriaca; 1992; 19 Suppl 1():25-8. PubMed ID: 1519447.
    Abstract:
    Cerebrospinal fluid (CSF) transthyretin (TTR), the main CSF thyroxine (T4) carrier protein in the rat and the human is synthesized in the choroid plexus (CP). After injection of 125I-T4 in the rat, radioactive T4 accumulates first in the CP, then in the CSF and later in the brain. We have shown that competitive inhibition of T4-TTR binding sites in the CP and CSF by a flavonoid results in a decrease in the radioactivity present in the brain after i.v. injection of 125I-T4, suggesting that T4 transported to the CSF via the CP is a significant pathway for the supply of thyroid hormones to the brain.
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