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  • Title: Impact of erythropoietic activity on red cell parameters in chronic renal failure patients.
    Author: Bovy C, Krzesinski JM, Gothot A, Beguin Y.
    Journal: Haematologica; 2004 Jun; 89(6):748-9. PubMed ID: 15194543.
    Abstract:
    We measured red cell parameters during recombinant human erythropoietin (rHuEPO) therapy associated with appropriate iron supplementation in chronic hemodialysis patients. Increased erythropoietic activity led to a bias in red cell parameter determination. The percentage of hypochromic red blood cells, usually used as the most effective predictor of response to iron supplementation, increased following the appearance of a younger red cell population since the same Hb content in these younger, larger cells gives a lower Hb concentration.
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