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  • Title: Hepatitis C virus-associated pericardial effusion and tamponade in a liver transplant recipient.
    Author: Nikolaidis LA, Azzouz M, Friedlander L, Van Thiel DH, Gradman AH.
    Journal: Can J Cardiol; 2004 May 15; 20(7):719-21. PubMed ID: 15197425.
    Abstract:
    A liver transplant recipient with hepatitis C presented with unexplained dyspnea, fatigue and edema. Diagnostic evaluation revealed a pericardial effusion with echocardiographic features of tamponade. The patient underwent therapeutic pericardial drainage, resulting in symptomatic relief. The pericardial fluid tested positive for hepatitis C virus (viral quantitation of 200,000 copies/mL, genotype 1b) and negative for other plausible etiologies. Pericardial biopsy revealed normal tissue. This is the fifth case of hepatitis C virus-associated pericardial disease worldwide and the first case in North America. It is the first in a liver transplant recipient. In contrast to previous reports, this patient demonstrated tamponade in the absence of cryoglobulinemia or systemic extrahepatic manifestations of hepatitis C.
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