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  • Title: Neuropathology of primary restless leg syndrome: absence of specific tau- and alpha-synuclein pathology.
    Author: Pittock SJ, Parrett T, Adler CH, Parisi JE, Dickson DW, Ahlskog JE.
    Journal: Mov Disord; 2004 Jun; 19(6):695-9. PubMed ID: 15197711.
    Abstract:
    The neuroanatomical substrate for restless legs syndrome (RLS) is unknown. We identified 4 patients with idiopathic RLS who came to post-mortem examination, where brain and spinal cord tissue were available for neuropathological assessment. Lewy bodies were not identified and alpha-synuclein immunohistochemistry was uniformly negative. Neurofibrillary tangle pathology was variable and nonspecific. These findings suggest that tau- or alpha-synuclein brain pathology is not a component of primary RLS. Although chronic ischemic changes were found in all 4 cases, these were probably incidental. The absence of diagnostic microscopic brain or spinal cord pathology suggests that the pathologic substrate may be neurochemical or receptor based.
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