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  • Title: [Effectiveness and tolerability of amisulpride in patients with schizophrenia: results of a 6-month open study].
    Author: Rzewuska M, Kuczyński W, Luks M.
    Journal: Psychiatr Pol; 2004; 38(3):453-68. PubMed ID: 15199655.
    Abstract:
    AIM: 6-month multicentre, observational, open study evaluated the efficacy and tolerability of the new generation antipsychotic drug amisulpride in patients with acute schizophrenia. METHOD: 99 patients were included in the study, 72 (72%) completed the 6-month observation. RESULTS: Marked improvement in CGI after 6 months of treatment was observed in 56 (56%) patients. Therapy with amisulpride reduced both positive (20% reduction of positive symptoms in the PANSS positive subscale in 78%) and negative symptoms (20% reduction of negative symptoms in the PANSS negative subscale in 77%). CONCLUSION: Amisulpride was well tolerated, adverse events responsible for premature withdrawal from the study were observed only in 6% patients.
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