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  • Title: [Hairy cell leukemia, Japanese variant, successfully treated with cladribine].
    Author: Miyazaki M, Taguchi A, Sakuragi S, Mitani N, Matsuda K, Shinohara K.
    Journal: Rinsho Ketsueki; 2004 May; 45(5):405-7. PubMed ID: 15199752.
    Abstract:
    A 67-year-old male was admitted because of lymphocytosis and huge splenomegaly. Abnormal lymphocytes had cytoplasmic hairy projections and were negative for tartrate-resistant acid phosphatase staining. The bone marrow aspirate contained many lymphocytes with the same morphology. Flow cytometric analysis revealed an increase in IgM and kappa positive B cells. They were positive for CD11c, CD19, CD20 and FMC7, and negative for CD5, CD10 and CD25. The patient was diagnosed as having hairy cell leukemia, Japanese variant. Initially interferon-alpha was administered for a month, decreasing the numbers of leukemic cells but with little effect on splenomegaly. Subsequent administration of cladribine (0.09 mg/kg, 7 days) showed a remarkable effect, and the patient has been in complete remission for 8 months.
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