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  • Title: A case of hypertrophic osteoarthropathy associated with epithelioid hemangioendothelioma.
    Author: Kim JH, Lee EB, Kim S, Kang HW, Suh JW, Yoon WJ, Kim SH, Kang EH, Im CH, Song YW, Lee HS.
    Journal: J Korean Med Sci; 2004 Jun; 19(3):484-6. PubMed ID: 15201523.
    Abstract:
    Epithelioid hemangioendothelioma is a rare vascular tumor, which occurs in the lung, liver, bone, and soft tissue. Hypertrophic osteoarthropathy is a syndrome characterized by subperiosteal new bone formation, joint effusion and clubbing, and may be associated with cyanotic heart disease, chronic pulmonary disease, liver disease, and other miscellaneous diseases. The activation of endothelium and platelets has been suggested to be involved in the development of hypertrophic osteoarthropathy. We report a rare case of hypertrophic osteoarthropathy, which developed in association with hepatic epithelioid hemangioendothelioma with pulmonary metastasis. We also discuss the role of vascular endothelial growth factor in its pathogenesis.
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