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  • Title: A fetal case of transient abnormal myelopoiesis with severe liver failure in Down syndrome: prognostic value of serum markers.
    Author: Shiozawa Y, Fujita H, Fujimura J, Suzuki K, Sato H, Saito M, Shimizu T, Yamashiro Y.
    Journal: Pediatr Hematol Oncol; 2004; 21(3):273-8. PubMed ID: 15202167.
    Abstract:
    The authors recently encountered a lethal case of Down syndrome with transient abnormal myelopoiesis (TAM). Although the peripheral white blood cell count and blast cells had improved without specific treatment, the patient died of severe coagulopathy due to liver fibrosis when he was 5 years old. The prognosis of TAM with liver fibrosis was poor. The patient had high levels of N-terminal peptide of III procollagen, type IV collagen, and hyaluronic acid. These serum makers are noninvasive indicators of liver fibrosis and may be useful as prognostic indicators of TAM in Down syndrome.
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