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  • Title: Synthesis and antibacterial activity of O-substituted nocathiacin I derivatives.
    Author: Naidu BN, Sorenson ME, Hudyma T, Zheng X, Zhang Y, Bronson JJ, Pucci MJ, Clark JM, Ueda Y.
    Journal: Bioorg Med Chem Lett; 2004 Jul 16; 14(14):3743-6. PubMed ID: 15203154.
    Abstract:
    The synthesis and antibacterial activity of a series of new nocathiacin I derivatives (1-12) containing polar water solubilizing groups is described. Most of these compounds exhibited potent antibacterial activity and have improved water solubility. In addition, compounds 5, 7-9 also exhibited potent in vivo activity.
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