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  • Title: Estrogen receptor ligands. Part 6: Synthesis and binding affinity of dihydrobenzodithiins.
    Author: Tan Q, Birzin ET, Chan W, Yang YT, Pai LY, Hayes EC, DaSilva CA, DiNinno F, Rohrer SP, Schaeffer JM, Hammond ML.
    Journal: Bioorg Med Chem Lett; 2004 Jul 16; 14(14):3753-5. PubMed ID: 15203156.
    Abstract:
    Dihydrobenzodithiin compounds (1-6) were prepared to explore the expansion of the dihydrobenzoxathiin lead compounds I-III as SERAMs (Selective Estrogen Receptor Alpha Modulators). The dihydrobenzodithiin compounds generally maintained a high degree of selectivity for ERalpha over ERbeta, however, they lacked the in vivo antagonism/agonism activity exhibited by the lead class in an immature rat uterine growth model.
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