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  • Title: Antifouling activity of simple synthetic isocyanides against larvae of the barnacle Balanus amphitrite.
    Author: Nogata Y, Kitano Y, Yoshimura E, Shinshima K, Sakaguchi I.
    Journal: Biofouling; 2004 Apr; 20(2):87-91. PubMed ID: 15203962.
    Abstract:
    Twelve simple linear isocyanides were synthesized and examined for antifouling activity and toxicity against cyprid larvae of the barnacle, Balanus amphitrite. Larval settlement was inhibited, with EC50 values of 0.046-1.90 microg ml(-1), and they were much less toxic (LD50 values ranging over 21.28 microg ml(-1)) than CuSO4 (EC50 0.30 microg ml(-1) and LD50 2.95 microg ml(-1)). The data indicate that simple linear isocyanides are promising non-toxic antifouling agents.
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