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  • Title: Inducible NO synthase inhibits the growth of free tumor cells, but enhances the growth of solid tumors.
    Author: Nishikawa M, Chang B, Inoue M.
    Journal: Carcinogenesis; 2004 Nov; 25(11):2101-5. PubMed ID: 15205363.
    Abstract:
    To elucidate the role of nitric oxide (NO) in tumor cell growth in vivo, dynamic aspects of the growth of Ehrlich ascites tumor cells (EATCs) were studied in wild-type (WT) mice and in an inducible strain of NO synthase (iNOS)-deficient (iNOS(-/-)) mice. Kinetic analysis showed that the rate of free tumor cell growth in the peritoneal cavity was significantly higher in the iNOS(-/-) mice than in the WT mice. In contrast, EATCs inoculated subcutaneously rapidly grew and formed a solid tumor in WT mice, but failed to grow in iNOS(-/-) mice. These results clearly indicate that NO generated by iNOS predominantly inhibits the growth of tumor cells in their free form, but enhances the growth of solid tumors.
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