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  • Title: [Impact of dust storm PM2.5 and PM10 on the phagocytic function of alveolar macrophages of rat].
    Author: Huang X, Jin Y, Guo X, Wang Y.
    Journal: Wei Sheng Yan Jiu; 2004 Mar; 33(2):154-7. PubMed ID: 15208993.
    Abstract:
    OBJECTIVE: To investigated effects of dust storm PM2.5 and PM10 on the phagocytosis of rat alveolar macrophages. METHODS: PM2.5 and PM10 were collected during dust storm period in the urban area of Beijing. Cytotoxicity of PM2.5 and PM10 was measured by MTT method. Flow cytometry analysis was applied to characterize effects of PM2.5 and PM10 on the phagocytosis of alveolar macrophages. RESULTS: PM2.5 and PM10 were toxic to rat alveolar macrophages at the concentrations above 20 micrograms/ml. PM2.5 and PM10 impaired phagocytic function of alveolar macrophages in a dose-dependent manner. PM2.5 was more potent than PM10. CONCLUSION: Dust storm PM2.5 and PM10 could impair the phagocytosis of rat alveolar macrophages, that may in turn impair the airway nonspecific defenses function.
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