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  • Title: Immunohistochemical study of microvessel density, CD44 (standard form), p53 protein and c-erbB2 in gallbladder carcinoma.
    Author: Kalekou H, Miliaras D.
    Journal: J Gastroenterol Hepatol; 2004 Jul; 19(7):812-8. PubMed ID: 15209630.
    Abstract:
    BACKGROUND: The purpose of the present study was to investigate microvessel density (MVD), and the expression of CD44 adhesion molecule, p53 protein and c-erbB2 in gallbladder carcinoma, and their relation to histological grade and tumor invasiveness. METHODS: Immunohistochemical staining with antibodies against factor VIIIRAg, CD44 standard form (CD44s), p53 protein and c-erbB2 was performed on paraffin sections from 33 cases of gallbladder carcinoma. RESULTS: Significant increase of MVD with increasing depth of invasion (P < 0.02) was observed. No association of MVD with histological differentiation, CD44s, p53 and c-erbB2 protein expression was found. The expression of p53 protein was significantly higher in deeply invasive tumors (P = 0.028) and in moderately and poorly differentiated carcinomas (P < 0.05). The CD44s expression was higher in well-differentiated carcinomas (P < 0.05). c-erbB2 expression was found in 30.4% of tumors studied, but did not relate to any other parameters. CONCLUSION: Microvessel density and p53 protein expression increase progressively with increasing tumor invasiveness in gallbladder carcinomas. Microvessel density, p53 protein, CD44s, and perhaps c-erbB2 expression may be implicated in gallbladder carcinoma evolution.
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