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  • Title: [Effect of exogenous basic fibroblast growth factor on proliferation and migration of endothelial cells of partial thickness scald in rats].
    Author: Cheng B, Fu X, Sheng Z.
    Journal: Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi; 2004 May; 18(3):200-4. PubMed ID: 15211836.
    Abstract:
    OBJECTIVE: To observe the proliferation and migration of endothelial cells after 30% total burn surface area (TBSA) of deep partial thickness scald, and the effect of basic fibroblast growth factor (bFGF) on angiogenesis during wound healing. METHODS: A total of 133 male Wistar rats were divided randomly into normal control (n = 7), injured control group (n = 42), bFGF group (n = 42) and anti-c-fos group (n = 42). The apoptosis expression of fibroblasts was determined with in situ hybridization and the changes of proliferation cell nuclear antigen (PCNA), focal adhesion rinase(FAK), c-fos and extracellular signal-regulated kinase(ERK) proteins expression were detected with immunohistochemistry staining technique after 3 hours, 6 hours, 1 day, 3 days, 7 days, 14 days and 21 days of scald. RESULTS: In injured control group and bFGF group, the proliferation rate of the vascular endothelial had evident changes 7 days and 14 days after scald; the expression of FAK was increased 14 days after scald. ERK proteins expression was different between injury control group and bFGF group at initial stage after scald. Stimulation of ERKs by bFGF led to up-regulation of c-fos and strong expression of FAK. CONCLUSION: Exogenous bFGF extended the influence on wound healing process by ERK signaling pathway, affecting migration cascade of vascular endothelial cell. The oncogene proteins play an important role on accelerating angiogenesis during wound healing.
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