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  • Title: A simple but remarkably effective device for forming the C8-C14 polycyclic ring system of halichondrin B.
    Author: Namba K, Jun HS, Kishi Y.
    Journal: J Am Chem Soc; 2004 Jun 30; 126(25):7770-1. PubMed ID: 15212512.
    Abstract:
    A simple device consisting of two ion-exchange columns, two alumina-based filters, and a pump (Figure 1) was assembled to form the C8-C14 polycyclic ring system present in the halichondrin B class of marine natural products. The effectiveness of this device was tested for three substrates. In each case, the desired polycyclic ketal 3, 5, or 7 was obtained almost quantitatively in a single operation.
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