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  • Title: Propofol anaesthesia in malignant hyperpyrexia susceptible swine.
    Author: Foster PS, Hopkinson KC, Denborough MA.
    Journal: Clin Exp Pharmacol Physiol; 1992 Mar; 19(3):183-6. PubMed ID: 1521353.
    Abstract:
    1. Malignant hyperpyrexia (MH) is an inherited muscle abnormality that presents clinically as a syndrome of life-threatening complications during general anaesthesia. 2. Propofol is a new sedative hypnotic used for the induction and maintenance of anaesthesia. 3. Propofol did not induce MH in five susceptible pigs. Propofol did not induce contracture in isolated MH susceptible muscle but did modify halothane, caffeine and KCl contractures.
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