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  • Title: Inhibitory activity of diarylheptanoids on farnesyl protein transferase.
    Author: Kang HM, Son KH, Yang DC, Han DC, Kim JH, Baek NI, Kwon BM.
    Journal: Nat Prod Res; 2004 Aug; 18(4):295-9. PubMed ID: 15214479.
    Abstract:
    Diarylheptanoids [curcumin (1), demethoxycurcumin (2), bisdemethoxycurcumin (3), bisdimethoxymethylcurcumin (4), and 1,2-dihydrobis(de-O-methyl)curcumin (5)] were isolated from the methanolic extract of Curcuma longa L. and a new cyclic diarylheptanoid (6) and a known Compound 7 were isolated from fruits of Alnus japonica Steud. Diarylheptanoids (1-3) inhibited farnesyl protein transferase (FPTase) with an IC50 of 29-50 microM. The other compounds very mildly inhibited FPTase, therefore, the inhibitory activity on FPTase very much depends on the structure of diarylheptanoids.
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