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  • Title: High-level fluoroquinolone resistance in a clinical Streptoccoccus pyogenes isolate in Germany.
    Author: Reinert RR, Lütticken R, Al-Lahham A.
    Journal: Clin Microbiol Infect; 2004 Jul; 10(7):659-62. PubMed ID: 15214881.
    Abstract:
    An isolate of Streptococcus pyogenes isolated from a 63-year-old woman with a serious wound infection was found to be highly resistant to fluoroquinolones (levofloxacin MIC > or = 32 mg/L). DNA amplification and sequencing revealed a serine-81 to phenylalanine substitution in gyrA and three substitutions in parC: serine-79 to phenylalanine, aspartic acid-91 to asparagine, and serine-140 to proline. To our knowledge, this is the first report from a European country of a clinical isolate of S. pyogenes with high-level fluoroquinolone resistance.
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