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  • Title: Evolution of acquired resistance to third-generation cephalosporins in Enterobacteriaceae in a Tunisian hospital 1993-2001.
    Author: Boutiba-Ben Boubaker I, Ghozzi R, Ben Abdallah H, Mamlouk K, Kamoun A, Ben Redjeb S.
    Journal: Clin Microbiol Infect; 2004 Jul; 10(7):665-7. PubMed ID: 15214883.
    Abstract:
    Between January 1993 and December 2001, the overall frequency of resistance to third-generation cephalosporins in isolates of Enterobacteriaceae from Charles Nicolle Hospital, Tunis, rose from 2.4% to 7.4%. Klebsiella pneumoniae was the most prevalent species (56%), followed by Escherichia coli (15%) and Proteus mirabilis (9%). A rate of 49% was observed among isolates from paediatric patients in 1999, caused mostly by outbreaks in the neonatal intensive care unit of K. pneumoniae and P. mirabilis isolates that produced extended-spectrum beta-lactamases.
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