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  • Title: Sustained-release formulation of doxycycline hyclate for prophylaxis of tick bite infection in a murine model of Lyme borreliosis.
    Author: Zeidner NS, Brandt KS, Dadey E, Dolan MC, Happ C, Piesman J.
    Journal: Antimicrob Agents Chemother; 2004 Jul; 48(7):2697-9. PubMed ID: 15215128.
    Abstract:
    The prophylactic potential of a single injection of sustained-release doxycycline hyclate (Atridox) was compared to that of a single oral dose of doxycycline hyclate in a murine model of Lyme borreliosis. Prophylaxis, as measured by the lack of cultivable spirochetes and demonstrable pathology, was noted for 43% of orally treated mice; in contrast, the sustained-release doxycycline hyclate completely protected mice from infection and resultant pathology.
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