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  • Title: Enhanced post-source decay and cross-ring fragmentation of oligosaccharides facilitated by conversion to amino derivatives.
    Author: Muzikar J, Mechref Y, Huang Y, Novotny MV.
    Journal: Rapid Commun Mass Spectrom; 2004; 18(13):1513-8. PubMed ID: 15216514.
    Abstract:
    Post-source decay (PSD) fragmentation of chemically or enzymatically produced aminoglycans has been evaluated through matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry. Conversion of native glycans to their respective aminoglycan derivatives improved detection sensitivity of the usual fragments and promoted cross-ring fragmentation of linear oligosaccharides, facilitating linkage recognition. The cross-ring fragmentations for both dextrin and dextran oligosaccharides were not limited to the reducing-end glucose moiety, as they were extended throughout the entire molecule. When the amino group was generated for N-glycans derived from three different glycoproteins, an enhancement of PSD was observed, without a significant extent of cross-ring fragmentation.
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