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  • Title: Cytotoxic triterpenoids from Acridocarpus vivy from the Madagascar rain forest.
    Author: Cao S, Guza RC, Miller JS, Andriantsiferana R, Rasamison VE, Kingston DG.
    Journal: J Nat Prod; 2004 Jun; 67(6):986-9. PubMed ID: 15217279.
    Abstract:
    Bioassay-guided fractionation of the cytotoxic MeOH extract obtained from Acridocarpus vivy led to the isolation of five new triterpenoids, acridocarpusic acids A-E (1-5); three known triterpenoids, moronic acid (6), ursolic acid, and oleanolic acid; and two known flavonoids, 4',5-dihydroxy-7-methoxyflavone and 4',5-dihydroxy-3',7-dimethoxyflavone. The structures of the new compounds 1-5 were established on the basis of extensive 1D and 2D NMR spectroscopic data interpretation. Compound 3 showed significant cytotoxic activity in the A2780 assay, with an IC50 value of 0.7 microg/mL.
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