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  • Title: IL-10 treatment of macrophages bolsters intracellular survival of Mycobacterium leprae.
    Author: Fukutomi Y, Matsuoka M, Minagawa F, Toratani S, McCormick G, Krahenbuhl J.
    Journal: Int J Lepr Other Mycobact Dis; 2004 Mar; 72(1):16-26. PubMed ID: 15217319.
    Abstract:
    In these studies, metabolically active Mycobacterium leprae were maintained for as long as 8 weeks in monolayer cultures of mouse peritoneal macrophages (MPhi). Supplemental IL-10, but not TGF-beta, bolstered, directly or indirectly, M. leprae metabolism in mouse MPhi. In the cell culture system temperature setting is extremely important and 31 to 33 degrees C incubation temperature was more permissive than 37 degrees C. Acid fast staining and transmission electron microscopy (TEM) of intracellular M. leprae revealed visible elongation of bacilli cultured under the above ideal conditions.
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