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  • Title: False-positive human serum chorionic gonadotropin in a patient with a history of germ cell cancer.
    Author: Trojan A, Joller-Jemelka H, Stahel RA, Jacky E, Hersberger M.
    Journal: Oncology; 2004; 66(4):336-8. PubMed ID: 15218303.
    Abstract:
    Tumor markers, including the beta-subunit of human chorionic gonadotropin (beta-hCG), and radiological imaging methods are commonly used for the diagnosis and monitoring of testicular cancer. We report of a patient with a history of classical seminoma stage I who had elevated serum levels of beta-hCG suggesting relapse 5 years after initial treatment. Radiological evaluation revealed a pericardial cyst, which was surgically removed. Histological evaluation did not demonstrate malignant tissue, suggesting a false-positive beta-hCG. Further workup confirmed this suspicion as we could demonstrate false-positive test results due to heterophilic antibodies detectable in the patient's serum. This case stresses the need for verification of beta-hCG levels in patients where clinical results are not in line with laboratory results.
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