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  • Title: [Minimal changes nephrotic syndrome associated to penicillamine treatment].
    Author: Basterrechea MA, de Arriba G, García-Martín F, Sánchez-Heras M, Giménez-Vega E, Sánchez J.
    Journal: Nefrologia; 2004; 24(2):183-7. PubMed ID: 15219094.
    Abstract:
    We describe three patients with minimal change nephrotic syndrome associated with penicillamine treatment. Two patients had systemic sclerosis and one had rheumatoid arthritis. Cumulative dose of D-penicillamine was similar in all cases, and nephrotic syndrome appeared after 15-33 months of treatment. The drug was stopped and nephrotic syndrome disappeared in 2-4 months, suggesting a possible causal relationship between penicillamine and minimal change disease.
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