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  • Title: Synthesis and assessment of [11C]acetylhomotaurine as an imaging agent for the study of the pharmacodynamic properties of acamprosate by positron emission tomography.
    Author: Courtyn J, Cornelissen B, Oltenfreiter R, Vandecapelle M, Slegers G, Strijckmans K.
    Journal: Nucl Med Biol; 2004 Jul; 31(5):649-54. PubMed ID: 15219284.
    Abstract:
    Acetylhomotaurine was labeled with (11)C via N-acetylation with [(11)C]acetyl chloride. The synthesis yielded 48.2+/-3.8%, decay corrected to end of bombardment. The specific activity of the (radio)chemically pure product was 20.8+/-2.0 GBq/micromol at EOS. In vivo studies revealed a very fast clearance of the tracer from the blood and a uniform distribution in the different brain regions. Unfortunately, the poor passage through the blood brain barrier makes the tracer not suitable for PET studies.
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