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  • Title: Contribution of bone-marrow-derived cells to choroidal neovascularization.
    Author: Takahashi H, Yanagi Y, Tamaki Y, Muranaka K, Usui T, Sata M.
    Journal: Biochem Biophys Res Commun; 2004 Jul 23; 320(2):372-5. PubMed ID: 15219837.
    Abstract:
    We investigated the involvement of bone-marrow derived cells to experimental choroidal neovascularization (CNV) in mice, whose bone marrow was reconstituted by either unfractionated bone-marrow cells or Lin-c(-)Kit(+)Sca-1+ enriched presumable hematopoietic stem cells from the green fluorescent protein (GFP) transgeneic mice. Immunohistochemical analysis demonstrated the presence of GFP-positive cells in the CNV lesion after unfractionated bone-marrow transplantation, as well as Lin-c(-)Kit(+)Sca-1+ cell transplantation. Some of the GFP-expressing cells also expressed CD-31 and PanEC antigen, markers of vascular endothelial cells. Our results suggest that bone-marrow derived cells may contribute endothelial cells in CNV.
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