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  • Title: Therapeutic amniocentesis for treatment of twin-twin transfusion syndrome.
    Author: Has R, Akhan S, Topuz S, Ermiş H, Iyibozkurt C, Ibrahimoğlu L.
    Journal: Arch Gynecol Obstet; 2005 Jan; 271(1):22-5. PubMed ID: 15221324.
    Abstract:
    OBJECTIVE: The objective was to determine whether therapeutic amniocentesis may improve outcomes in patients with twin-twin transfusion syndrome. STUDY DESIGN: Eleven patients were managed aggressively with repetitive serial amniocenteses, and six patients were managed conservatively. RESULTS: The time interval between diagnosis and delivery was 17.4 days more in the amniodrainage group, but the difference between the groups was not significant (68.3+/-41.9 days in the therapeutic amniocentesis group and 50.83+/-29.7 days in the expectant management group [p=0.384]). The overall survival rate of the two groups was 38.2%, and was not significantly different between groups (40.9% in the amniocentesis group and 33.3% in the expectant management group; p=1.00). Two of nine (22.2%) infants in the amnioreduction group, and one of four (25.0%) infants in the expectantly managed group had neurological symptoms. CONCLUSION: Our results did not show a significant benefit of aggressive therapeutic amniocentesis. A slight improvement in perinatal outcome was observed.
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