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  • Title: Diverse and potent activities of HGF/SF in skin wound repair.
    Author: Bevan D, Gherardi E, Fan TP, Edwards D, Warn R.
    Journal: J Pathol; 2004 Jul; 203(3):831-8. PubMed ID: 15221943.
    Abstract:
    Genetic studies in the mouse have highlighted essential roles for several growth factors in skin repair and have offered a rationale for their use in therapy. The present study shows that the plasminogen-related growth factor HGF/SF (hepatocyte growth factor/scatter factor) promotes wound repair in homozygous diabetic db/db mice by recruiting neutrophils, monocytes, and mast cells to the wound; by promoting the migration of endothelial cells to the injured area; and by enhancing keratinocyte migration and proliferation. As a result, granulation tissue formation, wound angiogenesis, and re-epithelialization are all increased. The results demonstrate that HGF/SF affects and sustains all key cellular processes responsible for wound repair and point to a unique potential of this molecule for the therapy of chronic skin wounds.
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