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  • Title: [Efficacy and safety of weekly taxol (TXL) for advanced recurrent breast cancer evaluated in a multi-center cooperative clinical trial].
    Author: Nishi T, Yamanaka E, Yamasaki M, Tanaka H, Takeda C, Ikeda N, Hoashi T, Higaki J, Matsunami T, Nakano K, Kogire M, Furukawa J, Inui N, Yamauchi E, Takagaki K, Ogino N, Nomura T, Yamada S, Fujimoto M, Uenishi M, Yayoi E, Osaka Breast Cancer Treatment Group.
    Journal: Gan To Kagaku Ryoho; 2004 Jun; 31(6):897-901. PubMed ID: 15222108.
    Abstract:
    A multi-center cooperative clinical trial was undertaken to evaluate the safety and efficacy of weekly taxol (TXL) therapy combined with short-premedication as a pretreatment in an effort to determine if TXL can be used in ambulatory treatment. TXL was administered at 60 mg/m2 to patients with advanced recurrent breast cancer once a week without a rest or with a rest for 1 week after treatment for 3 weeks. A total of 36 patients were finally enrolled. The site of recurrence was the local region in 8 patients, lung/pleura in 24, liver in 9, bone in 16, lymph nodes in 15, epicardium in 2, and brain metastasis in 2. The response was CR in 2, PR in 12, NC in 9, PD in 8, and NE in 5, with a response rate of 45.2%. Grade 4 anorexia was reported as non-hematotoxicity. All other adverse reactions, such as myalgia/arthralgia and peripheral neuropathy, were mild (grade 1 or 2). Hematotoxic effects observed in this study included only grade 3 leukopenia in 5 patients, neutropenia in 4, and decreases in hemoglobin in 1.
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