These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: High frequency of deletional alpha-thalassemia in beta-thalassemia trait: implications for genetic counseling.
    Author: Panigrahi I, Rafeeq PH, Choudhry VP, Saxena R.
    Journal: Am J Hematol; 2004 Jul; 76(3):297-9. PubMed ID: 15224373.
    Abstract:
    Thalassemias are a group of genetic hemolytic disorders with varying phenotypes. In this study, the frequency of alpha globin gene deletions was studied in the beta-thalassemia trait, the mildest form of the disorder. Eleven out of 33 (33%) individuals were positive for alpha(-3.7 kb) deletions. None of the subjects was positive for the Southeast Asian deletion. Such a high frequency for alpha deletions has not been reported earlier in thalassemia minor. Hematological parameters are compared, and implications of this finding for genetic counseling are discussed.
    [Abstract] [Full Text] [Related] [New Search]