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  • Title: Deep sinus aspergillosis in a liver transplant recipient successfully treated with a combination of caspofungin and voriconazole.
    Author: Tsiodras S, Zafiropoulou R, Giotakis J, Imbrios G, Antoniades A, Manesis EK.
    Journal: Transpl Infect Dis; 2004 Mar; 6(1):37-40. PubMed ID: 15225226.
    Abstract:
    We describe the rare case of a diabetic patient who was successfully treated for cytomegalovirus viremia and leishmaniasis following liver transplantation for hepatitis C virus-related cirrhosis, but also developed invasive sinus Aspergillus infection, while still on liposomal amphotericin B (AmBisome). The patient refused radical surgery including eye enucleation, and received a combination of intravenous caspofungin and voriconazole, along with repeated, conservative, local surgical debridement. At follow-up, 15 months after the onset of sinusitis, the patient remains culture-negative, fully active, and without evidence of local recurrence.
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