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  • Title: Application of multi-component reactions to antimalarial drug discovery. Part 1: Parallel synthesis and antiplasmodial activity of new 4-aminoquinoline Ugi adducts.
    Author: Musonda CC, Taylor D, Lehman J, Gut J, Rosenthal PJ, Chibale K.
    Journal: Bioorg Med Chem Lett; 2004 Aug 02; 14(15):3901-5. PubMed ID: 15225694.
    Abstract:
    The synthesis of a new class of Ugi adducts incorporating the 4-aminoquinoline moiety is described. The novel compounds are active against both chloroquine-sensitive and chloroquine-resistant strains of Plasmodium falciparum with the best compound showing an IC(50) value of 73 nM against a resistant K1 strain.
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