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  • Title: Design and synthesis of 3-(2-pyridyl)pyrazolo[1,5-a]pyrimidines as potent CRF1 receptor antagonists.
    Author: Huang CQ, Wilcoxen KM, Grigoriadis DE, McCarthy JR, Chen C.
    Journal: Bioorg Med Chem Lett; 2004 Aug 02; 14(15):3943-7. PubMed ID: 15225703.
    Abstract:
    A series of 3-(2-pyridyl)pyrazolo[1,5-a]pyrimidines was designed and synthesized as antagonists for the corticotrophin-releasing factor-1 (CRF(1)) receptor. Several compounds such as 20c (K(i)=10 nM) exhibited good binding affinities at the CRF(1) receptor. In addition, 20c had adequate solubility in water.
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