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  • Title: Synthesis of potent taxoids for tumor-specific delivery using monoclonal antibodies.
    Author: Miller ML, Roller EE, Wu X, Leece BA, Goldmacher VS, Chari RV, Ojima I.
    Journal: Bioorg Med Chem Lett; 2004 Aug 02; 14(15):4079-82. PubMed ID: 15225730.
    Abstract:
    The targeted delivery of taxoids, in the form of taxane-antibody immunoconjugates, requires the preparation of taxoids containing moieties suitable for their conjugation to monoclonal antibodies. A series of taxoids incorporating a disulfide-containing linker at various positions of the taxoid framework have been prepared to investigate the most suitable position for conjugation. A second series of taxoids modified at the C-2 position aimed at increasing the potency of these taxanes has also been prepared.
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