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  • Title: [Captopril and hydrochlorothiazide in treating arterial hypertension in the elderly patient. An enlarged case series and verification of the results].
    Author: Tamburrini LR, Ponte E, Vriz O, Di Monte M.
    Journal: Minerva Med; 1992; 83(7-8):461-6. PubMed ID: 1522971.
    Abstract:
    A group of 171 hypertensive patients were treated using 100 mg captopril and 50 mg hydrochlorothiazide over a period of four months. The group was subdivided into two subgroups of 138 elderly patients and 33 patients aged under sixty all of whom had a systolic blood pressure of over 180 mmHg, or over 160 mmHg if they had undergone previous treatment using another drug. Patients were monitored after one month and at the end of hypotensive therapy. The study showed a statistically significant reduction of blood pressure in both groups. In the elderly group blood pressure diminished from a mean basal level of 198.8/104.5 mmHg to 140.4/80.5 mmHg, whereas in the adult group pressure values were reduced from 190.1/108.4 mmHg to 134.0/80.6 mmHg. These results match those of an earlier study and, in conclusion, the Authors affirm that this combinations is a suitable "geriatric drug" since it responds to the needs of elderly hypertensive patients. Using captopril and hydrochlorothiazide it is possible to improve the quality of life of elderly hypertensive patients who are otherwise notoriously difficult to treat.
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