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  • Title: [Identification of narcotics in urine by capillary gas chromatography].
    Author: Akalaev AN, Shpagin MG, Shabolenko VP, Kovalenko AE.
    Journal: Sud Med Ekspert; 2004; 47(3):34-7. PubMed ID: 15230191.
    Abstract:
    It is demonstrated that gas chromatography with quartz capillary columns (QCC) and with cross-sewn SE-52 by polysiloxane provides for the possibility to divide and identify, in human urine, 16 narcotic substances of the amphetamine, 1.4-benzodiazepine, morphine and other groups. The suggested extraction method makes it possible to isolate the above compounds from urine simultaneously and, after derivatization, to determine them by gas chromatography (GC) with programmed temperature within one stage analysis session. GC tests were performed on 2 both foreign and Russian QCC with SE-52. There is a description of 2 methods of how to obtain the trifluor-acetyl derivatives (TFA-derivatives) by using trifluor-acetate anhydride and N-methyl-bis-trifluor-acetamide. The limit of detecting the TFA-derivatives was 1-2 ng for the plasma-ionizing detector. The extraction method as well as the positive and negative aspects of using the TFA-derivatives are under discussion. The method of gas-chromatography/mass-spectrometry confirms that the positive results of radioreceptor assay are verified by GC in 92% of cases.
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