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  • Title: Rapid tranquillisation of violent or agitated patients in a psychiatric emergency setting. Pragmatic randomised trial of intramuscular lorazepam v. haloperidol plus promethazine.
    Author: Alexander J, Tharyan P, Adams C, John T, Mol C, Philip J.
    Journal: Br J Psychiatry; 2004 Jul; 185():63-9. PubMed ID: 15231557.
    Abstract:
    BACKGROUND: The pharmacological management of violence in people with psychiatric disorders is under-researched. AIMS: To compare interventions commonly used for controlling agitation or violence in people with serious psychiatric disorders. METHOD: We randomised 200 people to receive intramuscular lorazepam (4 mg) or intramuscular haloperidol (10 mg) plus promethazine (25-50 mg mix). RESULTS: At blinded assessments 4 h later (99.5% follow-up), equal numbers in both groups (96%) were tranquil or asleep. However, 76% given the haloperidol-promethazine mix were asleep compared with 45% of those allocated lorazepam (RR=2.29,95% CI 1.59-3.39; NNT=3.2,95% CI 2.3-5.4). The haloperidol-promethazine mix produced a faster onset of tranquillisation/sedation and more clinical improvement over the first 2 h. Neither intervention differed significantly in the need for additional intervention or physical restraints, numbers absconding, or adverse effects. CONCLUSIONS: Both interventions are effective for controlling violent/agitated behaviour. If speed of sedation is required, the haloperidol-promethazine combination has advantages over lorazepam.
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