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  • Title: Effects of levonorgestrel, medroxyprogesterone acetate, norethindrone, progesterone, and 17beta-estradiol on thrombospondin-1 mRNA in Ishikawa cells.
    Author: Mirkin S, Archer DF.
    Journal: Fertil Steril; 2004 Jul; 82(1):220-2. PubMed ID: 15237017.
    Abstract:
    Abberant endometrial angiogenesis has been implicated in abnormal endometrial bleeding in users of progestin-only contraceptives. We believe that a possible cause is an underexpression of thrombospondin-1 (TSP-1). Progestins had less effects on TSP-1 mRNA compared to P, in Ishikawa cells, and this difference in TSP-1 expression by individual progestins may be associated with the irregular bleeding seen in women using progestin-only contraception.
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