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  • Title: Synthesis and antibacterial evaluation of 1beta-methyl-2-(5-substituted heterocyclic carbamoyl)pyrrolidin-3-ylthio)carbapenem derivatives.
    Author: Lee JS, Choa JH, Cho H, Oh CH.
    Journal: Arch Pharm (Weinheim); 2004 Jul; 337(7):391-7. PubMed ID: 15237389.
    Abstract:
    The synthesis of a new series of 1beta-methylcarbapenems having a substituted heterocyclic carbamoyl pyrrolidine moiety is described. Their in vitro antibacterial activity against both gram-positive and gram-negative bacteria was tested, and the effect of heterocyclic substituents on the pyrrolidine was investigated. One particular compound (III(d)) having a substituted oxadiazole moiety showed the most potent antibacterial activity.
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