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  • Title: Activation of natural killer cells: underlying molecular mechanisms revealed.
    Author: Backström E, Kristensson K, Ljunggren HG.
    Journal: Scand J Immunol; 2004; 60(1-2):14-22. PubMed ID: 15238069.
    Abstract:
    Natural killer (NK) cells, the third major lymphocyte population, are important effector cells against certain infections and tumours. They have also been implicated as a link between innate and adaptive immune responses. In recent years, much attention has been paid to the NK cell inhibitory receptors and their interaction with major histocompatibility complex class I molecules on target cells. This review summarizes recent findings on regulation of NK cell activity with an emphasis on NK cell stimulatory receptors. A particular emphasis is devoted to the receptor NKG2D that is expressed on all NK cells.
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