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  • Title: Airway eicosanoids in acute severe respiratory syncytial virus bronchiolitis.
    Author: Sznajer Y, Westcott JY, Wenzel SE, Mazer B, Tucci M, Toledano BJ.
    Journal: J Pediatr; 2004 Jul; 145(1):115-8. PubMed ID: 15238918.
    Abstract:
    We prospectively studied the levels of eicosanoids in intubated patients with severe bronchiolitis and compared them to electively intubated non-infected infants. LeukotrieneE(4) (LTE(4)), leukotrieneB(4) (LTB(4)), and prostaglandinE(2) (PGE(2)) levels were significantly increased (P <.01) from endotracheal (ET) aspirates of infants with bronchiolitis compared with controls, as were urinary LTE(4) levels (P <.001). We conclude that eicosanoids are increased in the tracheal aspirates and urine of children with bronchiolitis.
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