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  • Title: [Urinary calcium and bone turnover markers].
    Author: de la Torre Vega JP, Amador Licona N, Zamora Mata L, Morales Ramos Ael J.
    Journal: Ginecol Obstet Mex; 2004 Jan; 72(1):23-8. PubMed ID: 15239561.
    Abstract:
    OBJECTIVE: To know the relationship between bone turnover markers and urinary calcium excretion with and without oral calcium load in postmenopausal and young women. PATIENTS AND METHOD: A cross-sectional study in 100 women (50 with normal menstrual cycle and 50 postmenopausal). After 5 days with a specific diet, urine of 24 hours, 2 hours in fasting, and 4 hours after oral calcium load was collected (the last urine collection was only done in 20 patients in each group. In these patients, an x-ray absorptiometry of distal forearm and vitamin D levels were evaluated too). Calcium, alkaline phosphatase, calcitonin, parathormone, N-telopeptides of type I collagen, and osteocalcin serum levels were measured in fasting. Creatinine and calcium were measured in urine to obtain the Ca/cr index. RESULTS: Postmenopausal women had lower calcitonin levels while the Ca/cr index of 2 hours in fasting was higher than the eumenoreic women. We found significant correlation between Ca/cr index of 2 hours with age (R = .21; p = .04), parathormone (R = .21; p = .04), and calcitonin levels (R = -.29; p = .005). There was not correlation with the urinary calcium excretion including the 4 hour postload collection with the biochemical markers of bone turnover or mineral bone density of distal forearm. CONCLUSIONS: The urinary Ca/Cr index of 2 hours in fasting is related to parathormone levels and has a negative relationship with calcitonin levels in postmenopausal women. However, the urinary calcium excretion after oral calcium load was not related with the bone turnover grade.
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